Dra. Laura Torres García

Publicaciones

• Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation

  Parkinson’s and Alzheimer’s diseases involve aggregation of α-synuclein, Tau, and amyloid-β, often coexisting in mixed pathologies. This study used BiFC to test α-synuclein–Tau interaction in cell cultures and rodent models. Fluorescence signals confirmed their interaction in vitro and in vivo, particularly in the substantia nigra, demonstrating that these proteins interact in biologically relevant conditions and that BiFC is a useful tool to study these interactions.

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• Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure

  Microglia, the CNS immune cells, show strong regional heterogeneity in morphology, density, and inflammatory responses. This study examined their reaction across 16 brain regions after LPS-induced systemic inflammation, assessing morphological changes, sensitivity, and progression to chronic inflammation. Distinct region-specific responses were found, especially in the substantia nigra, with associated synaptic alterations. Partial CX3CR1 ablation reduced microglial activation and prevented chronic inflammation, highlighting it as a potential therapeutic target.

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• Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

  Synaptic dysfunction is an early feature of Alzheimer’s disease, with ApoE4 as a key genetic risk factor. This study shows ApoE localizes near synapses and modulates neuronal activity depending on its source. Astrocyte-derived ApoE4 increases activity acutely, while neuron-derived ApoE3 drives higher firing rates. Effects differ in AD models, highlighting source- and isoform-specific roles of ApoE in neuronal excitability.

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